Research Papers

Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography

[+] Author Affiliations
Chenyang Xu, Joseph M. Schmitt

Lightlab Imaging Inc., 1 Technology Park Drive, Westford, Massachusetts 01886

Stephane G. Carlier

Cardiovascular Research Foundation, 55 East 59th Street, New York, New York 10022

Renu Virmani

CVPath Institute, 19 Firstfield Road, Gaithersburg, Maryland 20878

J. Biomed. Opt. 13(3), 034003 (June 05, 2008). doi:10.1117/1.2927464
History: Received October 04, 2007; Revised January 04, 2008; Accepted January 31, 2008; Published June 05, 2008
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Intravascular optical coherence tomography (OCT) has been proven a powerful diagnostic tool for cardiovascular diseases. However, the optical mechanism for the qualitative observations are still absent. We address the fundamental issues that underlie the tissue characterization of OCT images obtained from coronary arteries. For this, we investigate both the attenuation and the backscattering properties of different plaque components of postmortem human cadaver coronary arteries. The artery samples are examined both from lumen surface using a catheter and from transversely cut surface using an OCT microscope, where OCT images could be matched to histology exactly. Light backscattering coefficient μb and attenuation coefficients μt are determined for three basic plaque types based on a single-scattering physical model: calcification (μb=4.9±1.5mm1, μt=5.7±1.4mm1), fibers (μb=18.4±6.4mm1, μt=6.4±1.2mm1), and lipid pool (μb=28.1±8.9mm1, μt=13.7±4.5mm1). Our results not only explain the origins of many qualitative OCT features, but also show that combination of backscattering and attenuation coefficient measurements can be used for contrast enhancing and better tissue characterization.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Chenyang Xu ; Joseph M. Schmitt ; Stephane G. Carlier and Renu Virmani
"Characterization of atherosclerosis plaques by measuring both backscattering and attenuation coefficients in optical coherence tomography", J. Biomed. Opt. 13(3), 034003 (June 05, 2008). ; http://dx.doi.org/10.1117/1.2927464


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