Research Papers

Pulsed diode laser-based monitor for singlet molecular oxygen

[+] Author Affiliations
Seonkyung Lee, Leyun Zhu, Ahmed M. Minhaj, Michael F. Hinds, Danthu H. Vu, David I. Rosen, Steven J. Davis

Physical Sciences Inc., 20 New England Business Center, Andover, Massachusetts 01810-1077

Tayyaba Hasan

Massachusetts General Hospital, Wellman Laboratories of Photomedicine, 40 Blossom Street, Boston, Massachusetts 02114-2605

J. Biomed. Opt. 13(3), 034010 (June 05, 2008). doi:10.1117/1.2927465
History: Received November 09, 2007; Revised January 16, 2008; Accepted January 16, 2008; Published June 05, 2008
Text Size: A A A

Photodynamic therapy (PDT) is a promising cancer treatment. PDT uses the affinity of photosensitizers to be selectively retained in malignant tumors. When tumors, pretreated with the photosensitizer, are irradiated with visible light, a photochemical reaction occurs and tumor cells are destroyed. Oxygen molecules in the metastable singlet delta state O2(Δ1) are believed to be the species that destroys cancerous cells during PDT. Monitoring singlet oxygen produced by PDT may lead to more precise and effective PDT treatments. Our approach uses a pulsed diode laser-based monitor with optical fibers and a fast data acquisition system to monitor singlet oxygen during PDT. We present results of in vitro singlet oxygen detection in solutions and in a rat prostate cancer cell line as well as PDT mechanism modeling.

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Seonkyung Lee ; Leyun Zhu ; Ahmed M. Minhaj ; Michael F. Hinds ; Danthu H. Vu, et al.
"Pulsed diode laser-based monitor for singlet molecular oxygen", J. Biomed. Opt. 13(3), 034010 (June 05, 2008). ; http://dx.doi.org/10.1117/1.2927465


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.