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Research Papers

Photoacoustic imaging and temperature measurement for photothermal cancer therapy

[+] Author Affiliations
Jignesh Shah, Suhyun Park, Salavat Aglyamov, Timothy Larson

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

Li Ma

University of Texas at Austin, Department of Chemical Engineering, Austin, Texas 78712

Konstantin Sokolov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712 and M. D. Anderson Cancer Center, Department of Biomedical Engineering, Houston, Texas 77030

Keith Johnston

University of Texas at Austin, Department of Chemical Engineering, Austin, Texas 78712

Thomas Milner, Stanislav Y. Emelianov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

J. Biomed. Opt. 13(3), 034024 (August 07, 2007December 18, 2007December 18, 2007June 23, 2008). doi:10.1117/1.2940362
History: Received August 07, 2007; Revised December 18, 2007; Accepted December 18, 2007; Published June 23, 2008
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Photothermal therapy is a noninvasive, targeted, laser-based technique for cancer treatment. During photothermal therapy, light energy is converted to heat by tumor-specific photoabsorbers. The corresponding temperature rise causes localized cancer destruction. For effective treatment, however, the presence of photoabsorbers in the tumor must be ascertained before therapy and thermal imaging must be performed during therapy. This study investigates the feasibility of guiding photothermal therapy by using photoacoustic imaging to detect photoabsorbers and to monitor temperature elevation. Photothermal therapy is carried out by utilizing a continuous wave laser and metal nanocomposites broadly absorbing in the near-infrared optical range. A linear array-based ultrasound imaging system is interfaced with a nanosecond pulsed laser to image tissue-mimicking phantoms and ex-vivo animal tissue before and during photothermal therapy. Before commencing therapy, photoacoustic imaging identifies the presence and spatial location of nanoparticles. Thermal maps are computed by monitoring temperature-induced changes in the photoacoustic signal during the therapeutic procedure and are compared with temperature estimates obtained from ultrasound imaging. The results of our study suggest that photoacoustic imaging, augmented by ultrasound imaging, is a viable candidate to guide photoabsorber-enhanced photothermal therapy.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Jignesh Shah ; Li Ma ; Konstantin Sokolov ; Keith Johnston ; Thomas Milner, et al.
"Photoacoustic imaging and temperature measurement for photothermal cancer therapy", J. Biomed. Opt. 13(3), 034024 (August 07, 2007December 18, 2007December 18, 2007June 23, 2008). ; http://dx.doi.org/10.1117/1.2940362


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