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Special Section on Selected Topics in Biophotonics: Diffuse Optics and Optical Molecular Imaging

White Monte Carlo for time-resolved photon migration

[+] Author Affiliations
Erik Alerstam, Stefan Andersson-Engels, Tomas Svensson

Lund University, Department of Physics, Sweden

J. Biomed. Opt. 13(4), 041304 (September 18, 2007November 13, 2007November 16, 2007July 09, 2008). doi:10.1117/1.2950319
History: Received September 18, 2007; Revised November 13, 2007; Accepted November 16, 2007; Published July 09, 2008
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A novel scheme for fully scalable White Monte Carlo (WMC) has been developed and is used as a forward solver in the evaluation of experimental time-resolved spectroscopy. Previously reported scaling problems are avoided by storing detection events individually, turning spatial and temporal binning into post-simulation activities. The approach is suitable for modeling of both interstitial and noninvasive settings (i.e., infinite and semi-infinite geometries). Motivated by an interest in in vivo optical properties of human prostate tissue, we utilize WMC to explore the low albedo regime of time-domain photon migration—a regime where the diffusion approximation of radiative transport theory breaks down, leading to the risk of overestimating both reduced scattering (μs) and absorption (μa). Experimental work supports our findings and establishes the advantages of Monte Carlo–based evaluation.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Erik Alerstam ; Stefan Andersson-Engels and Tomas Svensson
"White Monte Carlo for time-resolved photon migration", J. Biomed. Opt. 13(4), 041304 (September 18, 2007November 13, 2007November 16, 2007July 09, 2008). ; http://dx.doi.org/10.1117/1.2950319


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