Research Papers

In vivo detection of reduced scattering coefficient of C6 glioma in rat brain tissue by near-infrared spectroscopy

[+] Author Affiliations
Lijuan Dai, Zhiyu Qian

Nanjing University of Aeronautics and Astronautics, Department of Biomedical Engineering, No. 29 Yuado Street, Nanjing, Jiangsu 210016, China

Kuanzheng Li, Tianming Yang

Southeast University, College of Medicine, Nanjing, Jiangsu 210009, China

Huinan Wang

Nanjing University of Aeronautics and Astronautics, Department of Biomedical Engineering, No. 29 Yuado Street, Nanjing, Jiangsu 210016, China

J. Biomed. Opt. 13(4), 044003 (August 08, 2008). doi:10.1117/1.2957974
History: Received July 19, 2007; Revised January 21, 2008; Accepted March 12, 2008; Published August 08, 2008
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The purpose of this study is to investigate the reduced scattering coefficient of C6 glioma by the near-infrared (NIR) technique. Light scattering properties of C6 glioma in brain tissue is measured by NIR spectroscopy within the wavelength range from 700to850nm. C6 gliomas were implanted in rats’ right brains. The scattering properties of the left and right target corresponding to the position of normal and tumor tissue were measured by a bifurcated needle probe on postoperative days 3, 10, and 17. The results show that there was no significant difference in reduced scattering coefficient between left and right brain tissue at postoperative day 3, but significant decreases were found between left and right brains at postoperative days 10 and 17. This study proved our initial hypothesis that the NIR technique may have a potential for clinical application in brain μglioma diagnosis.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Lijuan Dai ; Zhiyu Qian ; Kuanzheng Li ; Tianming Yang and Huinan Wang
"In vivo detection of reduced scattering coefficient of C6 glioma in rat brain tissue by near-infrared spectroscopy", J. Biomed. Opt. 13(4), 044003 (August 08, 2008). ; http://dx.doi.org/10.1117/1.2957974


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