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Research Papers

Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints

[+] Author Affiliations
Zhen Yuan, Qizhi Zhang

University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611-6131

Eric S. Sobel

University of Florida, College of Medicine, Division of Rheumatology, Gainesville, Florida 32611

Huabei Jiang

University of Florida, Department of Biomedical Engineering, Gainesville, Florida 32611-6131

J. Biomed. Opt. 13(4), 044006 (September 27, 2007February 22, 2008February 26, 2008August 08, 2008). doi:10.1117/1.2965547
History: Received September 27, 2007; Revised February 22, 2008; Accepted February 26, 2008; Published August 08, 2008
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We describe a multimodality imaging approach that combines x-ray tomosynthesis with near-infrared diffuse optical tomography (DOT) for high-resolution imaging of osteoarthritis in the finger joints. In this approach, we take advantage of high resolution x-ray imaging particularly of the bones and incorporate the fine structural maps obtained from x ray as a priori information into DOT reconstructions. To realize this multi-modality approach, we constructed a hybrid imaging platform that integrated a C-arm–based x-ray tomosynthetic system with a multichannel optic-fiber–based DOT system. We also implemented improved hybrid regularization-based reconstruction algorithms that have shown to be especially effective for high-resolution modality-guided DOT. Initial evaluation of our x-ray–guided DOT reconstruction approach in the finger joints shows that spatial resolution of DOT can be enhanced dramatically when the three-dimensional geometry of bones is known a priori. In particular, the improved quantitative capability of imaging absorption and scattering coefficients of the joint tissues allows for more accurate diagnosis of osteoarthritis over x-ray radiography or DOT alone.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Zhen Yuan ; Eric S. Sobel ; Huabei Jiang and Qizhi Zhang
"Tomographic x-ray–guided three-dimensional diffuse optical tomography of osteoarthritis in the finger joints", J. Biomed. Opt. 13(4), 044006 (September 27, 2007February 22, 2008February 26, 2008August 08, 2008). ; http://dx.doi.org/10.1117/1.2965547


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