Research Papers

Monkey brain cortex imaging by photoacoustic tomography

[+] Author Affiliations
Xinmai Yang, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, St. Louis, Missouri, 63130

J. Biomed. Opt. 13(4), 044009 (August 20, 2008). doi:10.1117/1.2967907
History: Received November 25, 2007; Revised March 03, 2008; Accepted March 04, 2008; Published August 20, 2008
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Photoacoustic tomography (PAT) is applied to image the brain cortex of a monkey through the intact scalp and skull ex vivo. The reconstructed PAT image shows the major blood vessels on the monkey brain cortex. For comparison, the brain cortex is imaged without the scalp, and then imaged again without the scalp and skull. Ultrasound attenuation through the skull is also measured at various incidence angles. This study demonstrates that PAT of the brain cortex is capable of surviving the ultrasound signal attenuation and distortion caused by a relatively thick skull.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Xinmai Yang and Lihong V. Wang
"Monkey brain cortex imaging by photoacoustic tomography", J. Biomed. Opt. 13(4), 044009 (August 20, 2008). ; http://dx.doi.org/10.1117/1.2967907


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