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Research Papers

Delineation of an oral cancer lesion with swept-source optical coherence tomography

[+] Author Affiliations
Meng-Tsan Tsai, Hsiang-Chieh Lee, Chih-Wei Lu, Yih-Ming Wang, Cheng-Kuang Lee, C. C. Yang

National Taiwan University, Institute of Photonics and Optoelectronics, Department of Electrical Engineering, 1 Roosevelt Road, Section 4, Taipei, Taiwan

Chun-Ping Chiang

National Taiwan University, Department of Dentistry, Taipei, Taiwan

J. Biomed. Opt. 13(4), 044012 (September 24, 2007January 08, 2008February 17, 2008August 08, 2008). doi:10.1117/1.2960632
History: Received September 24, 2007; Revised January 08, 2008; Accepted February 17, 2008; Published August 08, 2008
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We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8μm in free space and system sensitivity of 108dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally across the margin of a lesion. The other parameter is the standard deviation of the SS-OCT signal intensity fluctuation in an A-scan. This parameter increases significantly when the A-scan point is moved across the transition region between the normal and abnormal portions. Such parameters are useful for determining the margins of oral cancer.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Meng-Tsan Tsai ; Chun-Ping Chiang ; Hsiang-Chieh Lee ; Chih-Wei Lu ; Yih-Ming Wang, et al.
"Delineation of an oral cancer lesion with swept-source optical coherence tomography", J. Biomed. Opt. 13(4), 044012 (September 24, 2007January 08, 2008February 17, 2008August 08, 2008). ; http://dx.doi.org/10.1117/1.2960632


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