JBO Letters

Design and testing of a miniature broadband frequency domain photon migration instrument

[+] Author Affiliations
Keun-Sik No, Richard Kwong, Albert Cerussi

University of California, Irvine, Beackman Laser Institute Laser Medical and Microbeam Program, 1110 Health Sciences Road, East, Irvine, California 92612

Pai H. Chou

University of California, Irvine, Electrical Engineering and Computer Science, 444F Engineering Tower, Irvine, California 92697

J. Biomed. Opt. 13(5), 050509 (October 29, 2008). doi:10.1117/1.2998473
History: Received February 18, 2008; Revised July 17, 2008; Accepted August 26, 2008; Published October 29, 2008
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A board-level broadband frequency domain photon migration (mini-FDPM) instrument has been constructed to replace a conventional network-analyzer-based FDPM instrument. The mini-FDPM instrument with four wavelengths (681, 783, 823, and 850nm), matches conventional FDPM instrument in performance (88dBm noise level, 100dB dynamic range) and bandwidth (1GHz), and recovers the same optical properties within about 6% in absorption and 4% in reduced scattering for liquid phantoms covering a wide range of relevant optical properties. Compared to the conventional FDPM instrument, the mini-FDPM instrument is more than 5× faster (200ms per 401 modulation frequencies) and several orders of magnitude less in size and cost. Standard fiber-optic-based probes can be used with the mini-FDPM instrument, which increases applications in a number of clinically relevant measurement scenarios. By drastically reducing size and cost, FDPM miniaturization lowers barriers to access and will help promote FDPM in clinical research problems. The mini-FDPM instrument forms the core of a modular broadband diffuse optical spectroscopy instrument that can be used for a variety of clinical problems in imaging and functional monitoring (i.e., breast/skin cancer, brain activation, and exercise physiology).

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Keun-Sik No ; Richard Kwong ; Pai H. Chou and Albert Cerussi
"Design and testing of a miniature broadband frequency domain photon migration instrument", J. Biomed. Opt. 13(5), 050509 (October 29, 2008). ; http://dx.doi.org/10.1117/1.2998473


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