Research Papers

Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography

[+] Author Affiliations
Junghwan Oh

University of Texas at Austin, Biomedical Engineering Department, Austin, Texas 78712 and Pukyong National University, Mechanical Engineering Department, Busan 608-739 Korea

Marc D. Feldman

University of Texas, Health Science Center at San Antonio, San Antonio, Texas 78229 and University of Texas at Austin, Biomedical Engineering Department, Austin, Texas 78712 and South Texas Veterans Health Care System, 7400 Merton Minter Boulevard, San Antonio, Texas 78229

Jihoon Kim

University of Texas at Austin, Biomedical Engineering Department, Austin, Texas 78712

Pramod Sanghi, Dat Do, J. Jacob Mancuso

University of Texas, Health Science Center at San Antonio, San Antonio, Texas 78229

Nate Kemp

University of Texas at Austin, Biomedical Engineering Department, Austin, Texas 78712

Mehmet Cilingiroglu

University of Texas, Health Science Center at San Antonio, San Antonio, Texas 78229

Thomas E. Milner

University of Texas at Austin, Biomedical Engineering Department, Austin, Texas 78712

J. Biomed. Opt. 13(5), 054006 (October 13, 2008). doi:10.1117/1.2985762
History: Received January 25, 2007; Revised April 04, 2008; Accepted April 10, 2008; Published October 13, 2008
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We demonstrate the detection of iron oxide nanoparticles taken up by macrophages in atherosclerotic plaque with differential phase optical coherence tomography (DP-OCT). Magneto mechanical detection of nanoparticles is demonstrated in hyperlipidemic Watanabe and balloon-injured fat-fed New Zealand white rabbits injected with monocrystalline iron oxide nanoparticles (MIONs) of <40nm diam. MIONs taken up by macrophages was excited by an oscillating magnetic flux density and resulting nanometer tissue surface displacement was detected by DP-OCT. Frequency response of tissue surface displacement in response to an externally applied magnetic flux density was twice the stimulus frequency as expected from the equations of motion for the nanoparticle cluster.

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Junghwan Oh ; Marc D. Feldman ; Jihoon Kim ; Pramod Sanghi ; Dat Do, et al.
"Detection of macrophages in atherosclerotic tissue using magnetic nanoparticles and differential phase optical coherence tomography", J. Biomed. Opt. 13(5), 054006 (October 13, 2008). ; http://dx.doi.org/10.1117/1.2985762


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