Research Papers

High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound

[+] Author Affiliations
Zhijia Yuan, Zhenguo Wang, Rubin Pan

SUNY at Stony Brook, Department of Biomedical Engineering, Stony Brook, New York 11794

Jingxuan Liu

SUNY at Stony Brook, Department of Pathology, Stony Brook, New York 11794

Harris Cohen

SUNY at Stony Brook, Department of Radiology, Stony Brook, New York 11794

Yingtian Pan

SUNY at Stony Brook, Department of Biomedical Engineering, Stony Brook, New York 11794

J. Biomed. Opt. 13(5), 054007 (September 12, 2008). doi:10.1117/1.2978059
History: Received May 10, 2007; Revised April 07, 2008; Accepted April 10, 2008; Published September 12, 2008
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A comparative study between 1.3-μm optical coherence tomography (OCT) and 40-MHz high-frequency ultrasound (HFUS) is presented to enhance imaging of bladder cancers ex vivo. A standard rat bladder cancer model in which transitional cell carcinoma (TCC) was induced by intravesical instillation of AY-27 cells was followed independently with both OCT and HFUS, and the image identifications were compared to histological confirmations. Results indicate that both OCT and HFUS were able to delineate the morphology of rat bladder [e.g., the urothelium (low backscattering/echo) and the underlying lamina propria and muscularis (high backscattering/echo]. OCT differentiated inflammatory lesions (e.g., edema, infiltrates and vasodilatation in lamina propria, hyperplasia) and TCC based on characterization of urothelial thickening and enhanced backscattering or heterogeneity (e.g., papillary features), which HFUS failed due to insufficient image resolution and contrast. On the other hand, HFUS was able to stage large T2 tumors that OCT failed due to limited imaging depth. The results suggest that multimodality cystoscopy combining OCT and HFUS may have the potential to enhance the diagnosis and staging of bladder cancers and to guide tumor resection, in which both high resolution (10μm) and enhanced penetration (>3mm) are desirable.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Zhijia Yuan ; Zhenguo Wang ; Rubin Pan ; Jingxuan Liu ; Harris Cohen, et al.
"High-resolution imaging diagnosis and staging of bladder cancer: comparison between optical coherence tomography and high-frequency ultrasound", J. Biomed. Opt. 13(5), 054007 (September 12, 2008). ; http://dx.doi.org/10.1117/1.2978059


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