Research Papers

Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system

[+] Author Affiliations
Louis Gagnon, Claudine Gauthier, Rick D. Hoge, Frédéric Lesage

Institut de Génie Biomédical, École Polytechnique de Montréal, C.P. 6079, succ. Centre-Ville, Montréal, Québec H3C 3A7, Canada

Juliette Selb, David A. Boas

Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129

J. Biomed. Opt. 13(5), 054019 (September 23, 2008). doi:10.1117/1.2982524
History: Received December 28, 2007; Revised May 02, 2008; Accepted May 06, 2008; Published September 23, 2008
Text Size: A A A

We present in vivo measurements of baseline physiology from five subjects with a four-wavelength (690, 750, 800, and 850nm) time-resolved optical system. The measurements were taken at four distances: 10, 15, 25, and 30mm. All distances were fit simultaneously with a two-layered analytical model for the absorption and reduced scattering coefficient of both layers. The thickness of the first layer, comprising the skin, scalp, and cerebrospinal fluid, was obtained from anatomical magnetic resonance images. The fitting procedure was first tested with simulations before being applied to in vivo measurements and verified that this procedure permits accurate characterization of the hemoglobin concentrations in the extra- and intracerebral tissues. Baseline oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations and oxygen saturation were recovered from in vivo measurements and compared to the literature. We observed a noticeable intersubject variability of the hemoglobin concentrations, but constant values for the cerebral hemoglobin oxygen saturation.

Figures in this Article
© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Louis Gagnon ; Claudine Gauthier ; Rick D. Hoge ; Frédéric Lesage ; Juliette Selb, et al.
"Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system", J. Biomed. Opt. 13(5), 054019 (September 23, 2008). ; http://dx.doi.org/10.1117/1.2982524


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.