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Research Papers

Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system

[+] Author Affiliations
Louis Gagnon, Claudine Gauthier, Rick D. Hoge, Frédéric Lesage

Institut de Génie Biomédical, École Polytechnique de Montréal, C.P. 6079, succ. Centre-Ville, Montréal, Québec H3C 3A7, Canada

Juliette Selb, David A. Boas

Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129

J. Biomed. Opt. 13(5), 054019 (December 28, 2007May 02, 2008May 06, 2008September 23, 2008). doi:10.1117/1.2982524
History: Received December 28, 2007; Revised May 02, 2008; Accepted May 06, 2008; Published September 23, 2008
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We present in vivo measurements of baseline physiology from five subjects with a four-wavelength (690, 750, 800, and 850nm) time-resolved optical system. The measurements were taken at four distances: 10, 15, 25, and 30mm. All distances were fit simultaneously with a two-layered analytical model for the absorption and reduced scattering coefficient of both layers. The thickness of the first layer, comprising the skin, scalp, and cerebrospinal fluid, was obtained from anatomical magnetic resonance images. The fitting procedure was first tested with simulations before being applied to in vivo measurements and verified that this procedure permits accurate characterization of the hemoglobin concentrations in the extra- and intracerebral tissues. Baseline oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations and oxygen saturation were recovered from in vivo measurements and compared to the literature. We observed a noticeable intersubject variability of the hemoglobin concentrations, but constant values for the cerebral hemoglobin oxygen saturation.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Louis Gagnon ; Juliette Selb ; David A. Boas ; Claudine Gauthier ; Rick D. Hoge, et al.
"Double-layer estimation of intra- and extracerebral hemoglobin concentration with a time-resolved system", J. Biomed. Opt. 13(5), 054019 (December 28, 2007May 02, 2008May 06, 2008September 23, 2008). ; http://dx.doi.org/10.1117/1.2982524


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