Research Papers

Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies

[+] Author Affiliations
Andrei B. Karpiouk

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

Salavat R. Aglyamov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712 and Russian Academy of Sciences, Institute of Mathematical Problems of Biology, Pushchino, Moscow Region, 142290, Russia

Srivalleesha Mallidi, Jignesh Shah

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

W. Guy Scott

WinProbe Corporation, North Palm Beach, Florida 33408

Jonathan M. Rubin

University of Michigan, Department of Radiology, Ann Arbor, Michigan 48109

Stanislav Y. Emelianov

University of Texas at Austin, Department of Biomedical Engineering, Austin, Texas 78712

J. Biomed. Opt. 13(5), 054061 (October 14, 2008). doi:10.1117/1.2992175
History: Received December 17, 2007; Revised June 17, 2008; Accepted August 05, 2008; Published October 14, 2008
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Treatment of deep venous thrombosis (DVT)—a primary cause of potentially fatal pulmonary embolism (PE)—depends on the age of the thrombus. The existing clinical imaging methods are capable of visualizing a thrombus but cannot determine the age of the blood clot. Therefore, there is a need for an imaging technique to reliably diagnose and adequately stage DVT. To stage DVT (i.e., to determine the age of the thrombus, and therefore, to differentiate acute from chronic DVT), we explored photoacoustic imaging, a technique capable of noninvasive measurements of the optical absorption in tissue. Indeed, optical absorption of the blood clot changes with age, since maturation of DVT is associated with significant cellular and molecular reorganization. The ultrasound and photoacoustic imaging studies were performed using DVT-mimicking phantoms and phantoms with embedded acute and chronic thrombi obtained from an animal model of DVT. The location and structure of the clots were visualized using ultrasound imaging, while the composition, and therefore age, of thrombi were related to the magnitude and spatiotemporal characteristics of the photoacoustic signal. Overall, the results of our study suggest that combined ultrasound and photoacoustic imaging of thrombi may be capable of simultaneous detection and staging of DVT.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Andrei B. Karpiouk ; Salavat R. Aglyamov ; Srivalleesha Mallidi ; Jignesh Shah ; W. Guy Scott, et al.
"Combined ultrasound and photoacoustic imaging to detect and stage deep vein thrombosis: phantom and ex vivo studies", J. Biomed. Opt. 13(5), 054061 (October 14, 2008). ; http://dx.doi.org/10.1117/1.2992175


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