Research Papers

Comparison of cerebral oxygen saturation in premature infants by near-infrared spatially resolved spectroscopy: observations on probe-dependent bias

[+] Author Affiliations
Line C. Sorensen

Copenhagen University Hospital, Department of Pediatrics and Neonatology, Hvidovre, Denmark and National University Hospital, Department of Neonatology, Rigshospitalet, Copenhagen, Denmark

Terence S. Leung

University College London, Department of Medical Physics and Bioengineering, London, United Kingdom

Gorm Greisen

National University Hospital, Department of Neonatology, Rigshospitalet, Copenhagen, Denmark and University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark

J. Biomed. Opt. 13(6), 064013 (November 19, 2008). doi:10.1117/1.3013454
History: Received March 31, 2008; Revised July 23, 2008; Accepted September 02, 2008; Published November 19, 2008
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Spatially resolved spectroscopy (SRS) allows the estimation of absolute tissue oxygen saturation, the ratio of oxygenated to total hemoglobin concentration, which may facilitate the comparison of results among patients. Eighty-two premature infants were included over two years. The cerebral tissue oxygenation index (c-TOI) was measured using NIRO 300 (Hamamatsu Photonics KK). c-TOI was measured at several positions in each infant. c-TOI varied over time, increasing in the first third and decreasing in the last third of the study period (p<106). Two probes were used in the study, and a highly significant difference was found between these (p<106). The mean difference was 8.5% (95%CI 5.4 to 11.6%). After correction for this difference, there was no variation over time. A conclusive explanation for the bias could not be identified. Since the study groups were well distributed, the bias had no influence on the results of our clinical study. We investigated an unexpected but highly significant probe-dependent bias in c-TOI with no conclusive explanation. Hence, comparisons of absolute TOI between groups of patients and among studies should be regarded with caution. A better strategy to detect potential instrumental problems will be useful in preventing biased c-TOI from occurring.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Line C. Sorensen ; Terence S. Leung and Gorm Greisen
"Comparison of cerebral oxygen saturation in premature infants by near-infrared spatially resolved spectroscopy: observations on probe-dependent bias", J. Biomed. Opt. 13(6), 064013 (November 19, 2008). ; http://dx.doi.org/10.1117/1.3013454


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