Research Papers

Detection of optical and mechanical property inhomogeneities in tissue mimicking phantoms using an ultrasound assisted optical probe

[+] Author Affiliations
C. Usha Devi

Thangal Kunju Musaliar College of Engineering, Department of Electrical and Electronics Engineering, Kollam, 691005, India

R. Sreekumari Bharat Chandran, R. Mohan Vasu

Indian Institute of Science, Department of Instrumentation, Bangalore, 560 012, India

Ajay K. Sood

Indian Institute of Science, Department of Physics, Bangalore, 560 012, India

J. Biomed. Opt. 13(6), 064025 (December 10, 2008). doi:10.1117/1.3041169
History: Received May 26, 2008; Revised October 02, 2008; Accepted October 08, 2008; Published December 10, 2008
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We discuss the issue of separating contributions from mechanical and optical properties of a moderately scattering tissue phantom to the modulation depth (M) of intensity autocorrelation measured in an ultrasound-assisted optical tomography system using axial and transverse illuminations. For axial illumination, M is affected by both the displacement and absorption coefficient, more prominently by displacement. But transverse illumination has very little contribution from displacement of scattering centers. Since displacement is related to the elastic property of the insonified region, we show that there is a possibility of separating the contributions from elastic and optical properties of the insonified region using axial and transverse illuminations. The main conclusions of our study using moderately scattering phantoms are: 1. axial illumination is the best for mapping storage modulus inhomogeneities, but M is also affected by optical absorption; 2. transverse illumination is the best for mapping absorption inhomogeneities; and 3. for the practically relevant case of an inclusion with larger storage modulus and absorption, both illuminations produced large contrast in M. When the scattering coefficient is high, the angle dependence of illumination is lost and the present method is shown to fail to separate these contributions based on direction of illumination.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

C. Usha Devi ; R. Sreekumari Bharat Chandran ; R. Mohan Vasu and Ajay K. Sood
"Detection of optical and mechanical property inhomogeneities in tissue mimicking phantoms using an ultrasound assisted optical probe", J. Biomed. Opt. 13(6), 064025 (December 10, 2008). ; http://dx.doi.org/10.1117/1.3041169


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