Research Papers

Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy

[+] Author Affiliations
Jangwoen Lee, Jae G. Kim, Sari Mahon, Bruce J. Tromberg

University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine, California 92612

Kathy L. Ryan, Victor A. Convertino, Caroline A. Rickards

U.S. Army Institute of Surgical Research, Fort Sam Houston, Texas 78234

Kathryn Osann

University of California, Irvine, Department of Medicine, 1002 Health Sciences Road East, Irvine, California 92612

Matthew Brenner

University of California, Irvine, Beckman Laser Institute and Medical Clinic, 1002 Health Sciences Road East, Irvine California 92612 and University of California, Irvine Medical Center, Pulmonary and Critical Care Division, Building 53, Room 119, 101 City Drive South, Orange, California 92868

J. Biomed. Opt. 13(6), 064027 (December 16, 2008). doi:10.1117/1.3041712
History: Received July 03, 2008; Revised October 10, 2008; Accepted October 10, 2008; Published December 16, 2008
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We demonstrate noninvasive near-infrared diffuse optical spectroscopy (DOS) measurements of tissue hemoglobin contents that can track progressive reductions in central blood volume in human volunteers. Measurements of mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), and cardiac output (Q) are obtained in ten healthy human subjects during baseline supine rest and exposure to progressive reductions of central blood volume produced by application of lower body negative pressure (LBNP). Simultaneous quantitative noninvasive measurements of tissue oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin concentration (THb), and tissue hemoglobin oxygen saturation (StO2) are performed throughout LBNP application using broadband DOS. As progressively increasing amounts of LBNP are applied, HR increases, and MAP, SV, and Q decrease (p<0.001). OHb, StO2, and THb decrease (p<0.001) in correlation with progressive increases in LBNP, while tissue RHb remained relatively constant (p=0.378). The average fractional changes from baseline values in DOS OHb (fOHb) correlate closely with independently measured changes in SV (r2=0.95) and Q (r2=0.98) during LBNP. Quantitative noninvasive broadband DOS measurements of tissue hemoglobin parameters of peripheral perfusion are capable of detecting progressive reductions in central blood volume, and appear to be sensitive markers of early hypoperfusion associated with hemorrhage as simulated by LBNP.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Jangwoen Lee ; Jae G. Kim ; Sari Mahon ; Bruce J. Tromberg ; Kathy L. Ryan, et al.
"Tissue hemoglobin monitoring of progressive central hypovolemia in humans using broadband diffuse optical spectroscopy", J. Biomed. Opt. 13(6), 064027 (December 16, 2008). ; http://dx.doi.org/10.1117/1.3041712


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