Research Papers

Estimation of mammographic density on an interval scale by transillumination breast spectroscopy

[+] Author Affiliations
Kristina M. Blackmore

Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 60 Murray Street, Toronto, Ontario M5T 3L9 Canada

Samantha Dick

Princess Margaret Hospital, UHN, Ontario Cancer Institute Division Biophysics and Bioimaging, 610 University Avenue, Rm. 8-303, Toronto, Ontario M5G 2M9, Canada

Julia Knight

Mount Sinai Hospital, Samuel Lunenfeld Research Institute, 60 Murray Street, Toronto, Ontario M5T 3L9 Canada and University of Toronto, Dalla Lana School of Public Health, 155 College Street, Toronto, Ontario M5T 3M7Canada

Lothar Lilge

Princess Margaret Hospital, UHN, Ontario Cancer Institute, Division Biophysics and Bioimaging, and, University of Toronto, Department of Medical Biophysics 610 University Avenue, Toronto, Ontario M5G 2M9Canada

J. Biomed. Opt. 13(6), 064030 (December 16, 2008). doi:10.1117/1.3041498
History: Received August 27, 2008; Revised October 17, 2008; Accepted October 17, 2008; Published December 16, 2008
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Transillumination breast spectroscopy (TiBS) uses nonionizing optical radiation to gain information about breast tissue morphological and structural properties. TiBS spectra are obtained from 232 women and compared to mammographic density (MD) quantified using Cumulus. The ability of TiBS to estimate MD is assessed using partial least-squares (PLS) regression methods, which requires TiBS spectra as input (X) and Cumulus MD as target (Y) data. Multiple PLS models are considered to determine the optimal processing technique(s) for the input (X) and target (Y) data. For each model, the association between TiBS estimated MD (Ŷ) and Cumulus MD (Y) is established using Spearman’s rank correlation and linear regression analysis. The model that best estimates MD has the fewest assumptions regarding target (Y) and spectral (X) processing. The Spearman’s correlation coefficient between predicted MD and Cumulus MD for this model is 0.88, with a regression slope (β) of 0.93 (95% CI 0.83–1.02) and an R2 of 0.78. The approximation of individual MD was within 10% of Cumulus MD for the majority of women (80%), without stratification on age, body mass index (BMI), and menopausal status. TiBS provides an alternative to mammography assessed MD enabling frequent and earlier use of MD as a risk marker in preventive oncology.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Kristina M. Blackmore ; Samantha Dick ; Julia Knight and Lothar Lilge
"Estimation of mammographic density on an interval scale by transillumination breast spectroscopy", J. Biomed. Opt. 13(6), 064030 (December 16, 2008). ; http://dx.doi.org/10.1117/1.3041498


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