Research Papers

Analysis of the fluorescence temporal point-spread function in a turbid medium and its application to optical imaging

[+] Author Affiliations
Sung-Ho Han, Salman Farshchi-Heydari, David J. Hall

University of California at San Diego, Moores Cancer Center and Department of Radiology, 3855 Health Sciences Drive, 0819, La Jolla, California 92093-0819

J. Biomed. Opt. 13(6), 064038 (December 18, 2008). doi:10.1117/1.3042271
History: Received July 10, 2008; Revised October 28, 2008; Accepted October 29, 2008; Published December 18, 2008
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A time-domain optical method to evaluate the concentration (n), lifetime (τ), and depth (d) of a fluorescent inclusion is described by the complete analysis of the fluorescence temporal point-spread function (TPSF). The behavior of parameters in the fluorescence TPSF is explored, and we demonstrate the method with experimental data from a localized fluorescent inclusion in scattering media to recover images of n, τ, and d. The method has potential application for in vivo fluorescence imaging.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Sung-Ho Han ; Salman Farshchi-Heydari and David J. Hall
"Analysis of the fluorescence temporal point-spread function in a turbid medium and its application to optical imaging", J. Biomed. Opt. 13(6), 064038 (December 18, 2008). ; http://dx.doi.org/10.1117/1.3042271


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