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Research Papers

Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption

[+] Author Affiliations
Stephen C. Kanick, Henricus J. C. M. Sterenborg, Arjen Amelink

Erasmus Medical Center, Department of Radiation Oncology, Center for Optical Diagnostics and Therapy, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands

J. Biomed. Opt. 13(6), 064042 (December 23, 2008). doi:10.1117/1.3050424
History: Received October 02, 2008; Revised November 06, 2008; Accepted November 07, 2008; Published December 23, 2008
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Differential path length spectroscopy (DPS) is a method of reflectance spectroscopy that utilizes a specialized fiber geometry to make the photon path length (τ) insensitive to variations in tissue optical properties over a wide range of absorption (μa) and total scattering (μs) coefficients, which are common within the ultraviolet/visible (UV/VIS) wavelength region. This study extends the description of τ to larger μa and smaller μs values, optical properties that are representative of the near-infrared region (NIR), a region where the DPS path length may be dependent on both coefficients. This study presents a novel empirical relationship between τ and the combined effect of both μa (range: 0.112mm1) and μs (range: 1.542mm1), anisotropy of 0.8, and is applicable to DPS probes containing a wide range of fiber diameters (range: 1001000μm). The results indicate that the simple empirical formula, including only one fitted parameter, is capable of accurately predicting τ over a wide range (r=0.985; range: 80940μm) and predictions are not biased versus μa or μs. This novel relationship is applicable to analysis of DPS measurements of tissue in both the UV/VIS and NIR wavelength regions and may provide information about the wavelength-specific tissue volume optically sampled during measurement.

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© 2008 Society of Photo-Optical Instrumentation Engineers

Citation

Stephen C. Kanick ; Henricus J. C. M. Sterenborg and Arjen Amelink
"Empirical model description of photon path length for differential path length spectroscopy: combined effect of scattering and absorption", J. Biomed. Opt. 13(6), 064042 (December 23, 2008). ; http://dx.doi.org/10.1117/1.3050424


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