Research Papers

Remittance at a single wavelength of 390nm to quantify epidermal melanin concentration

[+] Author Affiliations
Wim Verkruysse

University of California, Irvine Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

Lars O. Svaasand

Norwegian University of Science and Technology, Department of Electronics and Telecommunications, Trondheim 7006, Norway

Walfre Franco

Cutera, Inc., 3240 Bayshore Boulevard, Brisbane, California 94005

J. Stuart Nelson

University of California, Irvine Beckman Laser Institute, 1002 Health Sciences Road, Irvine, California 92612

J. Biomed. Opt. 14(1), 014005 (January 20, 2009). doi:10.1117/1.3065542
History: Received July 01, 2008; Revised November 12, 2008; Accepted November 13, 2008; Published January 20, 2009
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Objective quantification of epidermal melanin concentration (EMC) should be useful in laser dermatology to determine the individual maximum safe radiant exposure (IMSRE). We propose a single-wavelength remittance measurement at 390nm as an alternative optical method to determine EMC and IMSRE. Remittance spectra (360to740nm), melanin index (MI) measurements and the transient radiometric temperature increase, ΔT(t), upon skin irradiation with an Alexandrite laser (755nm, 3-ms pulse duration, 6Jcm2) were measured on 749 skin spots (arm and calf) on 23 volunteers (skin phototypes I to IV). Due to the shallow penetration depth and independence of blood oxygen saturation (isosbestic point), remittance at 390nm appears to provide better estimates for EMC and IMSRE than MI.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Wim Verkruysse ; Lars O. Svaasand ; Walfre Franco and J. Stuart Nelson
"Remittance at a single wavelength of 390nm to quantify epidermal melanin concentration", J. Biomed. Opt. 14(1), 014005 (January 20, 2009). ; http://dx.doi.org/10.1117/1.3065542


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