Research Papers

Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy

[+] Author Affiliations
Gerhard Pichler, Karin Grossauer, Elisabeth Peichl, Andrea Gaster

Medical University of Graz, Department of Pediatrics, Division of Neonatology, Auenbruggerplatz 30, 8036 Graz, Austria

Andrea Berghold, Gerold Schwantzer

Medical University of Graz, Institute for Medical Informatics, Statistics and Documentation, Auenbruggerplatz 2, 8036 Graz, Austria

Heinz Zotter, Wilhelm Müller, Berndt Urlesberger

Medical University of Graz, Department of Pediatrics, Division of Neonatology, Auenbruggerplatz 30, 8036 Graz, Austria

J. Biomed. Opt. 14(1), 014014 (February 04, 2009). doi:10.1117/1.3076193
History: Received July 21, 2008; Revised November 27, 2008; Accepted December 09, 2008; Published February 04, 2009
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One of the problems of near-infrared-spectroscopy (NIRS) measurements is low reproducibility. The aim of the present study was to introduce quality criteria to increase reproducibility of peripheral NIRS measurements. In a prospective cohort study in 40 neonates, repeated NIRS measurements were performed on the calf. During five “reapplication” periods (of NIRS optodes), five “measurements” (venous occlusions) were performed. Tissue oxygenation index (TOI), mixed venous oxygenation (SvO2), fractional oxygen extraction (FOE), hemoglobin flow (Hbflow), oxygen delivery (DO2), and oxygen consumption (VO2) were assessed. Measurements with linear changes during venous occlusions were included for further analysis (first quality criterion: R2>0.95). The second quality criterion was the equation 0TOISvO2(SaO2SvO2)×0.2. Variance components and mean standard deviations were analyzed after introduction of the quality criteria. Variance components of reapplication and measurement decreased after introduction of the second quality criterion (TOI: 46.6–35.0%, SvO2: 76.8–38.2%, FOE: 73.1–37.5%, Hbflow: 70.3–51.9%, DO2: 71.5–52.7%, and VO2: 70.9–63.8%). Mean standard deviations of TOI (6.6±3.0 to 4.7±3.2%), SvO2 (11.1±4.8 to 5.7±3.9%), FOE (11.3±4.8 to 5.9±4.0%), Hbflow (4.3±2.0 to 2.9±1.6μmol100mLmin), and DO2 (17.8±7.6 to 11.4±6.2μmol100mLmin) decreased significantly, too. Only 12% of measurements fulfilled both quality criteria. With the introduction of two quality criteria, test–retest variability of peripheral NIRS measurements decreased significantly and reproducibility increased significantly.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Gerhard Pichler ; Karin Grossauer ; Elisabeth Peichl ; Andrea Gaster ; Andrea Berghold, et al.
"Combination of different noninvasive measuring techniques: a new approach to increase accuracy of peripheral near infrared spectroscopy", J. Biomed. Opt. 14(1), 014014 (February 04, 2009). ; http://dx.doi.org/10.1117/1.3076193


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