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Research Papers

Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx

[+] Author Affiliations
Ali Sepehr

University of California, Irvine, Beckman Laser Institute, Irvine, California 92617 and University of California, Irvine Medical Center, Department of Otolaryngology—Head and Neck Surgery, Orange, California 92868

Jorge Perez

University of California, Irvine, Beckman Laser Institute, Irvine, California 92617

Jianping Su

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697and University of California, Irvine, Beckman Laser Institute, Irvine, California 92617

James M. Ridgway, David Vokes

University of California, Irvine, Beckman Laser Institute, Irvine, California 92617 and University of California, Irvine Medical Center, Department of Otolaryngology—Head and Neck Surgery, Orange, California 92868

Shuguang Guo, Lingfeng Yu

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 and University of California, Irvine, Beckman Laser Institute, Irvine, California 92617

Brian J. F. Wong

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 and University of California, Irvine, Beckman Laser Institute, Irvine, California 92617 and University of California, Irvine Medical Center, Department of Otolaryngology—Head and Neck Surgery, Orange, California 92868

Zhongping Chen

University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697 and University of California, Irvine, Beckman Laser Institute, Irvine, California 92617

J. Biomed. Opt. 14(1), 014017 (September 05, 2008December 06, 2008December 16, 2008February 11, 2009). doi:10.1117/1.3076198
History: Received September 05, 2008; Revised December 06, 2008; Accepted December 16, 2008; Published February 11, 2009
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Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office-based laryngoscopy examination is presented. An optical-ballast-based 4f optical relay system is proposed to realize variable working distance with a constant optical delay. In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Ali Sepehr ; Jorge Perez ; Jianping Su ; James M. Ridgway ; Shuguang Guo, et al.
"Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx", J. Biomed. Opt. 14(1), 014017 (September 05, 2008December 06, 2008December 16, 2008February 11, 2009). ; http://dx.doi.org/10.1117/1.3076198


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