Research Papers

Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study

[+] Author Affiliations
Wendy Tanamai, Cynthia Chen, Sara Siavoshi, Albert Cerussi

University of California, Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612

David Hsiang, John Butler

University of California Irvine Medical Center, Department of Oncological Surgery, 101 The City Drive, Orange, California 92868

Bruce Tromberg

University of California, Irvine, Beckman Laser Institute, Laser Medical and Microbeam Program, 1002 Health Sciences Road East, Irvine, California 92612

J. Biomed. Opt. 14(1), 014024 (January 20, 2009). doi:10.1117/1.3028012
History: Received August 23, 2007; Revised September 03, 2008; Accepted September 03, 2008; Published January 20, 2009
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Diffuse optical spectroscopy (DOS) has been used to monitor and predict the effects of neoadjuvant (i.e., presurgical) chemotherapy in breast cancer patients in several pilot studies. Because patients with suspected breast cancers undergo biopsy prior to treatment, it is important to understand how biopsy trauma influences DOS measurements in the breast. The goal of this study was to measure the effects of a standard core breast biopsy on DOS measurements of tissue deoxyhemoglobin, hemoglobin, water, and bulk lipid concentrations. We serially monitored postbiopsy effects in the breast tissue in a single subject (31-year-old premenopausal female) with a 37×18×20mm fibroadenoma. A baseline measurement and eight weekly postbiopsy measurements were taken with a handheld DOS imaging instrument. Our instrument used frequency domain photon migration combined with broadband steady-state spectroscopy to characterize tissues via quantitative measurements of tissue absorption and reduced scattering coefficients from 650to1000nm. The concentrations of significant near-infrared (NIR) absorbers were mapped within a 50cm2 area over the biopsied region. A 2-D image of a contrast function called the tissue optical index (TOI=deoxyhemoglobin×waterbulklipid) was generated and revealed that a minimum of 14days postbiopsy was required to return TOI levels in the biopsied area to their prebiopsy levels. Changes in the TOI images of the fibroadenoma also reflected the progression of the patient’s menstrual cycle. DOS could therefore be useful in evaluating both wound-healing response and the effects of hormone and hormonal therapies in vivo.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Wendy Tanamai ; Cynthia Chen ; Sara Siavoshi ; Albert Cerussi ; David Hsiang, et al.
"Diffuse optical spectroscopy measurements of healing in breast tissue after core biopsy: case study", J. Biomed. Opt. 14(1), 014024 (January 20, 2009). ; http://dx.doi.org/10.1117/1.3028012


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