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Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging

[+] Author Affiliations
Alexandru S. Biris

University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204

Dorin Boldor, Jason Palmer, William T. Monroe

Louisiana State University Agricultural Center, Department of Biological and Agricultural Engineering, Baton Rouge, Louisiana 70803

Meena Mahmood, Enkeleda Dervishi, Yang Xu, Zhongrui Li

University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204

Ekaterina I. Galanzha, Vladimir P. Zharov

University of Arkansas for Medical Sciences, Philips Classic Laser and Nanomedicine Laboratories, Little Rock, Arkansas 72205

J. Biomed. Opt. 14(2), 021007 (September 09, 2008January 17, 2009February 14, 2009April 28, 2009). doi:10.1117/1.3119135
History: Received September 09, 2008; Revised January 17, 2009; Accepted February 14, 2009; Published April 28, 2009
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Nanophotothermolysis with long laser pulses for treatment of scattered cancer cells and their clusters is introduced with the main focus on real-time monitoring of temperature dynamics inside and around individual cancer cells labeled with carbon nanotubes. This technique utilizes advanced time- and spatially-resolved thermal radiometry imaging for the visualization of laser-induced temperature distribution in multiple-point absorbing targets. The capability of this approach was demonstrated for monitoring of thermal effects under long laser exposure (from millisecond to seconds, wavelength 1064nm, maximum power 1W) of cervical cancer HeLa cells labeled with carbon nanotubes in vitro. The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Alexandru S. Biris ; Dorin Boldor ; Meena Mahmood ; Ekaterina I. Galanzha ; Vladimir P. Zharov, et al.
"Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging", J. Biomed. Opt. 14(2), 021007 (September 09, 2008January 17, 2009February 14, 2009April 28, 2009). ; http://dx.doi.org/10.1117/1.3119135


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