Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers

[+] Author Affiliations
David Rioux, Marie Laferrière

Ecole Polytechnique de Montréal, Département de Génie Physique, Laser Processing Laboratory, Case Postale 6079, Succursale Centre-ville, Montréal, Québec H3C 3A7, Canada

Alexandre Douplik

University Health Network, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada

Duoaud Shah, Lothar Lilge

University Health Network, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada

Andrei V. Kabashin, Michel M. Meunier

Ecole Polytechnique de Montréal, Département de Génie Physique, Laser Processing Laboratory, Case Postale 6079, Succursale Centre-ville, Montréal, Québec H3C 3A7, Canada

J. Biomed. Opt. 14(2), 021010 (March 05, 2009). doi:10.1117/1.3086608
History: Received September 03, 2008; Revised December 11, 2008; Accepted January 03, 2009; Published March 05, 2009
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We report the synthesis of novel inorganic contamination-free photosensitizers based on colloidal silicon nanoparticles prepared by laser ablation in pure deionized water. We show that such nanoparticles are capable of generating singlet oxygen (O21) under laser irradiation with a yield estimated at 10% of that of photofrin, which makes them a potential candidate for therapeutics, antiseptics, or disinfectants. We also discuss a model of O21 generation and the possibility for optimizing its release. Potential advantages of such novel inorganic photosensitizers include stable and nonphotobleaching O21 release, easy removal, and low dark toxicity.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

David Rioux ; Marie Laferrière ; Alexandre Douplik ; Duoaud Shah ; Lothar Lilge, et al.
"Silicon nanoparticles produced by femtosecond laser ablation in water as novel contamination-free photosensitizers", J. Biomed. Opt. 14(2), 021010 (March 05, 2009). ; http://dx.doi.org/10.1117/1.3086608


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