Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy

[+] Author Affiliations
Georgy S. Terentyuk

Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012, Russia

Galina N. Maslyakova, Leyla V. Suleymanova

Saratov Medical State University, 112 B. Kazachya, Saratov 410012, Russia

Nikolai G. Khlebtsov, Boris N. Khlebtsov

Russian Academy of Science, Institute of Biochemistry and Physiology of Plants and Microorganisms, 13 Prospekt Entuziastov, Saratov 410049, Russia

Garif G. Akchurin, Irina L. Maksimova

Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012, Russia

Valery V. Tuchin

Saratov State University, Department of Optics and Biophotonics, 83 Astrakhanskaya, Saratov 410012 Russia and Russian Academy of Science, Institute of Precise Mechanics and Control, 24 Rabochaya, Saratov 410028, Russia

J. Biomed. Opt. 14(2), 021016 (April 27, 2009). doi:10.1117/1.3122371
History: Received September 04, 2008; Revised March 04, 2009; Accepted March 04, 2009; Published April 27, 2009
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We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom and laboratory rats. Temperature distributions on the animal skin surface at hypodermic and intramuscular injection of gold nanoparticle suspensions and affectations by the laser radiation are measured in vivo with a thermal imaging system. The results of temperature measurements are compared with tissue histology.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Georgy S. Terentyuk ; Galina N. Maslyakova ; Leyla V. Suleymanova ; Nikolai G. Khlebtsov ; Boris N. Khlebtsov, et al.
"Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy", J. Biomed. Opt. 14(2), 021016 (April 27, 2009). ; http://dx.doi.org/10.1117/1.3122371


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