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Special Section on Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases

Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study

[+] Author Affiliations
Mikhail Kirillin

Institute of Applied Physics of the Russian Academy of Sciences, 603950 Ulyanov Street, 46, Nizhny Novgorod, Russia

Marina Shirmanova, Marina Sirotkina, Marina Bugrova

Nizhny Novgorod State Medical Academy, 603005, Minin and Pozharsky Square, 10/1, Nizhny Novgorod, Russia

Boris Khlebtsov

Institute of Biochemistry and Physiology of Plants and Microorganisms of the Russian Academy of Science, 410049, pr. Entuziastov, 13, Saratov, Russia

Elena Zagaynova

Nizhny Novgorod State Medical Academy, 603005, Minin and Pozharsky Square, 10/1, Nizhny Novgorod, Russia

J. Biomed. Opt. 14(2), 021017 (July 04, 2008December 22, 2008March 19, 2009April 23, 2009). doi:10.1117/1.3122373
History: Received July 04, 2008; Revised December 22, 2008; Accepted March 19, 2009; Published April 23, 2009
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The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the obtained contrast. To interpret the obtained experimental OCT images of skin and understand the mechanisms of contrasting, a set of Monte Carlo calculations is performed. The results of the simulations exhibit good qualitative agreement with the experimental images, and prove that the contrasting originates from the nanoparticles added, while the contrast of inclusion originates from the absence of nanoparticles within it and their presence in the surrounding area.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Mikhail Kirillin ; Marina Shirmanova ; Boris Khlebtsov ; Elena Zagaynova ; Marina Sirotkina, et al.
"Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study", J. Biomed. Opt. 14(2), 021017 (July 04, 2008December 22, 2008March 19, 2009April 23, 2009). ; http://dx.doi.org/10.1117/1.3122373


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