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Research Papers

Laser optoacoustic imaging system for detection of breast cancer

[+] Author Affiliations
Sergey A. Ermilov

Fairway Medical Technologies, Inc., 9431 West Sam Houston Parkway South, Houston, Texas 77099

Tuenchit Khamapirad

The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555

Andre Conjusteau

Fairway Medical Technologies, Inc., 9431 West Sam Houston Parkway South, Houston, Texas 77099

Morton H. Leonard

The University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555

Ron Lacewell, Ketan Mehta, Tom Miller, Alexander A. Oraevsky

Fairway Medical Technologies, Inc., 9431 West Sam Houston Parkway South, Houston, Texas 77099

J. Biomed. Opt. 14(2), 024007 (March 06, 2009). doi:10.1117/1.3086616
History: Received July 11, 2008; Revised January 07, 2009; Accepted January 07, 2009; Published March 06, 2009
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We designed, fabricated and tested the laser optoacoustic imaging system for breast cancer detection (LOIS-64), which fuses optical and acoustic imaging techniques in one modality by utilizing pulsed optical illumination and ultrawide-band ultrasonic detection of resulting optoacoustic (OA) signals. The system was designed to image a single breast slice in craniocaudal or mediolateral projection with an arc-shaped array of 64 ultrawide-band acoustic transducers. The system resolution on breast phantoms was at least 0.5mm. The single-channel sensitivity of 1.66mVPa was estimated to be sufficient for single-pulse imaging of 6to11mm tumors through the whole imaging slice of the breast. The implemented signal processing using the wavelet transform allowed significant reduction of the low-frequency (LF) acoustic noise, allowed localization of the optoacoustic signals from tumors, and enhanced the contrast and sharpened the boundaries of the optoacoustic images of the tumors. During the preliminary clinical studies on 27 patients, the LOIS-64 was able to visualize 18 out of 20 malignant lesions suspected from mammography and ultrasound images and confirmed by the biopsy performed after the optoacoustic tomography (OAT) procedure.

© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Sergey A. Ermilov ; Tuenchit Khamapirad ; Andre Conjusteau ; Morton H. Leonard ; Ron Lacewell, et al.
"Laser optoacoustic imaging system for detection of breast cancer", J. Biomed. Opt. 14(2), 024007 (March 06, 2009). ; http://dx.doi.org/10.1117/1.3086616


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