Research Papers

Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels

[+] Author Affiliations
Molly Rossow

University of California Irvine, Biomedical Engineering Department, 3120 Natural Sciences 2, Irvine, California 92697-2715

William W. Mantulin

University of California Irvine, Beckman Laser Institute, 1002 Health Sciences Rd, Irvine, California 92612

Enrico Gratton

University of California Irvine, Biomedical Engineering Department, 3120 Natural Sciences 2, Irvine, California 92697-2715

J. Biomed. Opt. 14(2), 024014 (March 06, 2009). doi:10.1117/1.3088203
History: Received August 28, 2008; Revised December 10, 2008; Accepted January 14, 2009; Published March 06, 2009
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Accurate blood flow measurements during surgery can improve an operation’s chance of success. We developed near-infrared spatio-temporal image spectroscopy (NIR-STICS), which has the potential to make blood flow measurements that are difficult to accomplish with existing methods. Specifically, we propose the technique and we show feasibility on phantom measurements. NIR-STICS has the potential of measuring the fluid velocity in small blood vessels (less than 1mm in diameter) and of creating a map of blood flow rates over an area of approximately 1cm2. NIR-STICS employs near-infrared spectroscopy to probe inside blood vessel walls and spatiotemporal image correlation spectroscopy to directly—without the use of a model—extract fluid velocity from the fluctuations within an image. We present computer simulations and experiments on a phantom system that demonstrate the effectiveness of NIR-STICS.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Molly Rossow ; William W. Mantulin and Enrico Gratton
"Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels", J. Biomed. Opt. 14(2), 024014 (March 06, 2009). ; http://dx.doi.org/10.1117/1.3088203


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