Research Papers

Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination

[+] Author Affiliations
Chulhong Kim, Kwang Hyun Song, Konstantin Maslov, Lihong V. Wang

Washington University in St. Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899

J. Biomed. Opt. 14(2), 024015 (March 06, 2009). doi:10.1117/1.3088224
History: Received October 01, 2008; Revised December 30, 2008; Accepted January 15, 2009; Published March 06, 2009
Text Size: A A A

We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in reflection mode. The system used intense acoustic bursts and a charge-coupled device (CCD) camera-based speckle contrast detection method. In addition, the implementation allows placing the tissue sample below (not within) an acoustic coupling water tank and scanning the tissue without moving the sample. Thus, the UOT system is more clinically applicable than previous transmission-mode systems. Furthermore, we have successfully imaged an ex vivo methylene-blue-dyed sentinel lymph node (SLN) embedded at a depth of 13mm in chicken breast tissue. This UOT system offers several advantages: noninvasiveness, nonionizing radiation, portability, cost effectiveness, and the possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT system is mapping SLNs in axillary staging for breast cancer patients.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Chulhong Kim ; Kwang Hyun Song ; Konstantin Maslov and Lihong V. Wang
"Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination", J. Biomed. Opt. 14(2), 024015 (March 06, 2009). ; http://dx.doi.org/10.1117/1.3088224


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.