Research Papers

Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography

[+] Author Affiliations
Regine Choe, Soren D. Konecky, Alper Corlu

University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104

Kijoon Lee

Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, Singapore 637457 and University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104

Turgut Durduran

University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104 and Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, Philadelphia, Pennsylvania 19104

David R. Busch, Saurav Pathak

University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104

Brian J. Czerniecki, Julia Tchou, Douglas L. Fraker

Hospital of the University of Pennsylvania, Department of Surgery, 3400 Spruce Street, Philadelphia, Pennsylvania 19104

Angela DeMichele

Hospital of the University of Pennsylvania, Department of Medicine (Hematology/Oncology), 3400 Spruce Street, Philadelphia, Pennsylvania 19104

Britton Chance

University of Pennsylvania, Department of Biochemistry & Biophysics, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104

Simon R. Arridge, Martin Schweiger

University College London, Department of Computer Science, Gower Street, London, WC1E 6BT, United Kingdom

Joseph P. Culver

Washington University, School of Medicine, Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis, Missouri 63110 and University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104

Mitchell D. Schnall

Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, Philadelphia, Pennsylvania 19104

Mary E. Putt

University of Pennsylvania, Department of Biostatistics & Epidemiology, 423 Guardian Drive, Philadelphia, Pennsylvania 19104

Mark A. Rosen

Hospital of the University of Pennsylvania, Department of Radiology, 3400 Spruce Street, Philadelphia, Pennsylvania 19104

Arjun G. Yodh

University of Pennsylvania, Department of Physics & Astronomy, 209 S. 33rd Street, Philadelphia, Pennsylvania 19104

J. Biomed. Opt. 14(2), 024020 (April 14, 2009). doi:10.1117/1.3103325
History: Received September 23, 2008; Revised January 22, 2009; Accepted January 23, 2009; Published April 14, 2009
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We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional in vivo imaging of human breast tumor based on large optical data sets. Images of oxy-, deoxy-, and total hemoglobin concentration as well as blood oxygen saturation and tissue scattering were reconstructed. Tumor margins were derived using the optical data with guidance from radiology reports and magnetic resonance imaging. Tumor-to-normal ratios of these endogenous physiological parameters and an optical index were computed for 51 biopsy-proven lesions from 47 subjects. Malignant cancers (N=41) showed statistically significant higher total hemoglobin, oxy-hemoglobin concentration, and scattering compared to normal tissue. Furthermore, malignant lesions exhibited a twofold average increase in optical index. The influence of core biopsy on DOT results was also explored; the difference between the malignant group measured before core biopsy and the group measured more than 1week after core biopsy was not significant. Benign tumors (N=10) did not exhibit statistical significance in the tumor-to-normal ratios of any parameter. Optical index and tumor-to-normal ratios of total hemoglobin, oxy-hemoglobin concentration, and scattering exhibited high area under the receiver operating characteristic curve values from 0.90 to 0.99, suggesting good discriminatory power. The data demonstrate that benign and malignant lesions can be distinguished by quantitative three-dimensional DOT.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Regine Choe ; Soren D. Konecky ; Alper Corlu ; Kijoon Lee ; Turgut Durduran, et al.
"Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography", J. Biomed. Opt. 14(2), 024020 (April 14, 2009). ; http://dx.doi.org/10.1117/1.3103325


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