Research Papers

Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue

[+] Author Affiliations
Kai Zhang, Wenkai Zhang

University of California at Berkeley, Department of Chemistry, Berkeley, California, 94720

Chia-Yi Yang

Taipei City Hospital, Department of Dermatology, Taipei, Taiwan

Haw Yang

University of California at Berkeley, Department of Chemistry, Berkeley, California, 94720

J. Biomed. Opt. 14(2), 024042 (April 23, 2009). doi:10.1117/1.3120491
History: Received August 08, 2008; Revised January 30, 2009; Accepted February 24, 2009; Published April 23, 2009
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Microstructures of unstained human melanoma skin tissues have been examined by multimodal nonlinear optical microscopy. The polarized shape of the individual melanoma cell can be readily recognized—a phenotype that has been identified in laboratory cultures as characteristic of proliferating melanocytes but has not been demonstrated in clinical instances. The results thus provide snapshots of invading melanoma cells in their native environment and suggest a practical means of connecting in vitro laboratory studies to in vivo processes.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Kai Zhang ; Wenkai Zhang ; Chia-Yi Yang and Haw Yang
"Bipolar cellular morphology of malignant melanoma in unstained human melanoma skin tissue", J. Biomed. Opt. 14(2), 024042 (April 23, 2009). ; http://dx.doi.org/10.1117/1.3120491


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