Research Papers

Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation

[+] Author Affiliations
Emilie Péry, Walter C. P. M. Blondel, Cédric Thomas

Nancy University, Automatic Control Research Centre (CRAN), Joint Research Unit (UMR) 7039 Nancy University, National Center for Scientific Research (CNRS), 2, avenue de la Forêt de Haye, F-54516 Vandoeuvre-lès-Nancy, France

François Guillemin

Nancy University, Automatic Control Research Centre (CRAN), Joint Research Unit (UMR) 7039 Nancy University, National Center for Scientific Research (CNRS), Anticancer centre “Centre Alexis Vautrin”, Avenue de Bourgogne, F-54511 Vandoeuvre-lès-Nancy, France

J. Biomed. Opt. 14(2), 024048 (April 30, 2009). doi:10.1117/1.3122368
History: Received March 17, 2008; Revised March 02, 2009; Accepted March 03, 2009; Published April 30, 2009
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This work is first a description of a statistical simulation algorithm developed for simulating the spectral absorption and emission of several fluorophores in an absorbing and diffusing multilayer model. Second, a detailed experimental validation of the simulation program is conducted on two sets of liquid and solid multilayer phantoms, containing one, two, or three fluorophores, within absorbing and scattering media. Experimental spatially resolved reflectance spectra are acquired in the wavelength band 400to800nm and compared to corresponding simulated spectra. The degree of similarity between experimentation and simulation data is quantified. The results obtained underline good correlations with mean errors varying from 2 to 10%, depending on the number of layers and on the complexity of the phantom’s composition.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Emilie Péry ; Walter C. P. M. Blondel ; Cédric Thomas and François Guillemin
"Monte Carlo modeling of multilayer phantoms with multiple fluorophores: simulation algorithm and experimental validation", J. Biomed. Opt. 14(2), 024048 (April 30, 2009). ; http://dx.doi.org/10.1117/1.3122368


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