Research Papers

Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning

[+] Author Affiliations
Shuo Tang

University of British Columbia, Department of Electrical and Computer Engineering, Vancouver, BC V6T1Z4, Canada

Woonggyu Jung

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Rd East, Irvine, California 92612

Daniel McCormick

Advanced MEMS, Inc., 2107 Dwight Way, Berkeley, California 94704

Tuqiang Xie, Jiangping Su, Yeh-Chan Ahn, Bruce J. Tromberg, Zhongping Chen

University of California, Irvine, Beckman Laser Institute, 1002 Health Sciences Rd East, Irvine, California 92612

J. Biomed. Opt. 14(3), 034005 (May 11, 2009). doi:10.1117/1.3127203
History: Received August 27, 2008; Revised February 25, 2009; Accepted March 11, 2009; Published May 11, 2009
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A multiphoton endoscopy system has been developed using a two-axis microelectromechanical systems (MEMS) mirror and double-cladding photonic crystal fiber (DCPCF). The MEMS mirror has a 2-mm-diam, 20-deg optical scanning angle, and 1.26-kHz and 780-Hz resonance frequencies on the x and y axes. The maximum number of resolvable focal spots of the MEMS scanner is 720×720 on the x and y axes, which indicates that the MEMS scanner can potentially support high-resolution multiphoton imaging. The DCPCF is compared with standard single-mode fiber and hollow-core photonic bandgap fiber on the basis of dispersion, attenuation, and coupling efficiency properties. The DCPCF has high collection efficiency, and its dispersion can be compensated by grating pairs. Three configurations of probe design are investigated, and their imaging quality and field of view are compared. A two-lens configuration with a collimation and a focusing lens provides the optimum imaging performance and packaging flexibility. The endoscope is applied to image fluorescent microspheres and bovine knee joint cartilage.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Shuo Tang ; Woonggyu Jung ; Daniel McCormick ; Tuqiang Xie ; Jiangping Su, et al.
"Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning", J. Biomed. Opt. 14(3), 034005 (May 11, 2009). ; http://dx.doi.org/10.1117/1.3127203


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