Research Papers

Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles

[+] Author Affiliations
Chang Soo Kim

University of California, Irvine, Department of Chemical Engineering and Materials Science, Irvine, California 92697 and Beckman Laser Institute, Irvine, California 92612

Petra Wilder-Smith, Yeh-Chan Ahn, Lih-Huei L. Liaw

University of California, Irvine, Beckman Laser Institute, Irvine, California 92612

Zhongping Chen

University of California, Irvine, Department of Biomedical Engineering, Department of Chemical Engineering and Materials Science, Irvine, California 92697 and Beckman Laser Institute, Irvine, California 92612

Young Jik Kwon

University of California, Irvine, Department of Pharmaceutical Sciences, Department of Chemical Engineering and Materials Science, Department of Biomedical Engineering, Irvine, California 92697

J. Biomed. Opt. 14(3), 034008 (May 12, 2009). doi:10.1117/1.3130323
History: Received October 08, 2008; Revised December 22, 2008; Accepted March 16, 2009; Published May 12, 2009
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Contrast in optical coherence tomography (OCT) images can be enhanced by utilizing surface plasmon resonant gold nanoparticles. To improve the poor in vivo transport of gold nanoparticles through biological barriers, an efficient delivery strategy is needed. In this study, the improved penetration and distribution of gold nanoparticles were achieved by microneedle and ultrasound, respectively, and it was demonstrated that this multimodal delivery of antibody-conjugated PEGylated gold nanoparticles enhanced the contrast in in vivo OCT images of oral dysplasia in a hamster model.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Chang Soo Kim ; Petra Wilder-Smith ; Yeh-Chan Ahn ; Lih-Huei L. Liaw ; Zhongping Chen, et al.
"Enhanced detection of early-stage oral cancer in vivo by optical coherence tomography using multimodal delivery of gold nanoparticles", J. Biomed. Opt. 14(3), 034008 (May 12, 2009). ; http://dx.doi.org/10.1117/1.3130323


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