Research Papers

Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence

[+] Author Affiliations
Reinhold Eichhorn

Praxis für Dermatologie, Kurfürstendamm 139, Berlin, 10711, Germany

Gerd Wessler

Praxis für Dermatologie, Kurfürstendamm 139, Berlin, 10711, Germany

Matthias Scholz, Dieter Leupold, Goran Stankovic

LTB Lasertechnik Berlin, Rudower Strasse 29, Berlin, 12489, Germany

Susanne Buder

Vivantes Klinikum Neukölln, Klinik für Dermatologie und Venerologie, Rudower Chaussee 48, Berlin, 12351, Germany

Markus Stücker, Klaus Hoffmann

Ruhr-Universität Bochum, Saint Josef Hospital, Gudrunstrasse 56, Bochum, 44791, Germany

J. Biomed. Opt. 14(3), 034033 (June 17, 2009). doi:10.1117/1.3155511
History: Received August 26, 2008; Revised April 06, 2009; Accepted April 16, 2009; Published June 17, 2009
Text Size: A A A

Because of the increasing incidence of skin cancer, interest in using the autofluorescence of skin tissue as a noninvasive tool for early diagnosis is enforced. Focus is especially on malignant melanotic melanoma. On the basis of a newly developed method to selectively excite melanin fluorescence of skin tissue by stepwise two-photon excitation with nanosecond laser pulses at 810nm, we have investigated information from this melanin fluorescence with respect to the differentiation of pigmented lesions. A distinct difference in the melanin fluorescence spectrum of malignant melanoma (including melanoma in situ) when compared to that of benign melanocytic lesions (i.e., common nevi) has been found for freshly excised samples as well as for histopathological samples. There is also specific fluorescence from dysplastic nevi. In this way, early detection of malignant melanoma is possible.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Reinhold Eichhorn ; Gerd Wessler ; Matthias Scholz ; Dieter Leupold ; Goran Stankovic, et al.
"Early diagnosis of melanotic melanoma based on laser-induced melanin fluorescence", J. Biomed. Opt. 14(3), 034033 (June 17, 2009). ; http://dx.doi.org/10.1117/1.3155511


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.