Research Papers

Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing

[+] Author Affiliations
Xiangqun Xu, Qiuhong Zhu, Chaojie Sun

Zhejiang Sci-Tech University, School of Science, Higher Education Park in Xiasha, Zhejiang, Hangzhou 310018, China

J. Biomed. Opt. 14(3), 034042 (June 18, 2009). doi:10.1117/1.3156827
History: Received February 02, 2009; Revised April 09, 2009; Accepted May 01, 2009; Published June 18, 2009
Text Size: A A A

Our previous studies have shown the ultrasound-induced skin optical clearing enhancement with topical application of glycerol on in vitro porcine skin and in vivo human skin. The objective of this study was to find more effective ultrasound-alcohol combinations on skin optical clearing. The effect of sonophoretic delivery (SP) in combination with a series of alcohols such as glycerol, propylene glycol, butanediol, butanol, polyethylene glycol (PEG200, PEG400) on skin optical clearing was investigated. Light transmittance and imaging depth of in vitro porcine skin were measured with spectroscopy and optical coherence tomography (OCT). Sixty percent alcohols and ultrasound (SP) with a frequency of 1MHz and a power of 0.75W over a 3-cm probe was simultaneously applied for 15min. Optical clearing capability of alcohols was much improved with the simultaneous application of ultrasound compared with alcohols alone. Light transmittance at 1276nm increased by 31% (butanol) to 57% (PEG200) at 60min, respectively. PEG200 with ultrasound exhibited 1.8-fold the clearing capability of PEG200 alone, which was the highest enhancement by ultrasound among the six alcohols. Sixty minutes of PEG200/SP exposure resulted in a significantly increased 1e light penetration depth of 1.43mm compared to 0.95mm for control in OCT measurement.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Xiangqun Xu ; Qiuhong Zhu and Chaojie Sun
"Assessment of the effects of ultrasound-mediated alcohols on skin optical clearing", J. Biomed. Opt. 14(3), 034042 (June 18, 2009). ; http://dx.doi.org/10.1117/1.3156827


Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

PubMed Articles
Advertisement
  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.