Research Papers

Monitoring muscle metabolic indexes by time-domain near-infrared spectroscopy during knee flex-extension induced by functional electrical stimulation

[+] Author Affiliations
Simona Ferrante

Politecnico di Milano, Dipartimento di Bioingegneria, Neuro Engineering and Medical Robotics Laboratory, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

Davide Contini

Politecnico di Milano, Dipartimento di Fisica and National Laboratory for Ultrafast and Ultraintense Optical Science-Istituto Nazionale di Fisica della Materia-Consiglio Nazionale delle Ricerche, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

Lorenzo Spinelli

Istituto di Fotonica e Nanotecnologie-Sezione di Milano-Consiglio Nazionale delle Ricerche, Piazza Leonardo Da Vinci 32, Milano, 20133, Italy

Alessandra Pedrocchi

Politecnico di Milano, Dipartimento di Bioingegneria, Neuro Engineering and Medical Robotics Laboratory, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

Alessandro Torricelli

Politecnico di Milano, Dipartimento di Fisica and Politecnico di Milano, Research Unit Istituto Italiano di Tecnologia, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

Franco Molteni

Ospedale Valduce, Centro di Riabilitazione Villa Beretta, Via Nazario Sauro 17, Costamasnaga, 23845, Italy

Giancarlo Ferrigno

Politecnico di Milano, Dipartimento di Bioingegneria, Neuro Engineering and Medical Robotics Laboratory, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

Rinaldo Cubeddu

Politecnico di Milano, Dipartimento di Fisica and National Laboratory for Ultrafast and Ultraintense Optical Science-Istituto Nazionale di Fisica della Materia- Consiglio Nazionale delle Ricerche and Istituto di Fotonica e Nanotecnologie-Sezione di Milano- Consiglio Nazionale delle Ricerche andPolitecnico di Milano, Research Unit Istituto Italiano di Tecnologia, Piazza Leonardo da Vinci 32, Milano, 20133, Italy

J. Biomed. Opt. 14(4), 044011 (July 27, 2009). doi:10.1117/1.3183802
History: Received December 05, 2008; Revised May 06, 2009; Accepted May 26, 2009; Published July 27, 2009
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A noninvasive methodology, combining functional electrical stimulation and time-domain near-infrared spectroscopy (TD-NIRS), is developed to verify whether stroke-altered muscular metabolism on postacute patients. Seven healthy subjects and nine postacute stroke patients undergo a protocol of knee flex-extension induced by quadricep electrical stimulation. During the protocol, TD-NIRS measurements are performed on both rectus femoris to investigate whether significant differences arise between able-bodied and stroke subjects and between patients’ paretic and healthy legs. During baseline, metabolic parameters do not show any significant differences among subjects. During stimulation, paretic limbs produce a knee angle significantly lower than healthy legs. During recovery, patients’ healthy limbs show a metabolic behavior correlated to able-bodied subjects. Instead, the correlation between the metabolic behavior of the paretic and able-bodied legs allows the definition of two patients’ subgroups: one highly correlated (R>0.87) and the other uncorrelated (R<0.08). This grouping reflects the patient functional condition. The results obtained on the most impaired patients suggest that stroke does not produce any systemic consequences at the muscle, but the metabolic dysfunction seems to be local and unilateral. It is crucial to enlarge the sample size of the two subgroups before making these preliminary results a general finding.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Simona Ferrante ; Davide Contini ; Lorenzo Spinelli ; Alessandra Pedrocchi ; Alessandro Torricelli, et al.
"Monitoring muscle metabolic indexes by time-domain near-infrared spectroscopy during knee flex-extension induced by functional electrical stimulation", J. Biomed. Opt. 14(4), 044011 (July 27, 2009). ; http://dx.doi.org/10.1117/1.3183802


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