Research Papers

Quantitative detection of chemical compounds in human hair with coherent anti-Stokes Raman scattering microscopy

[+] Author Affiliations
Maxwell Zimmerley, Chia-Yu Lin

University of California, Irvine, Department of Chemistry, Irvine, California 92697

David C. Oertel, Jennifer M. Marsh

The Procter & Gamble Company, 11810 East Miami River Road, Cincinnati, Ohio 45252

Jimmie L. Ward

The Procter & Gamble Company, 11510 Reed Hartman Highway, Cincinnati, Ohio 45252

Eric Olaf Potma

University of California, Irvine, Department of Chemistry, Irvine, California 92697

J. Biomed. Opt. 14(4), 044019 (August 05, 2009). doi:10.1117/1.3184444
History: Received March 20, 2009; Revised June 02, 2009; Accepted June 02, 2009; Published August 05, 2009
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Coherent anti-Stokes Raman scattering (CARS) microscopy is used to determine the distribution and concentration of selected compounds in intact human hair. By generating images based on ratiometric CARS contrast, quantitative concentration maps of both water and externally applied d-glycine are produced in the cortex of human hair fibers. Both water and d-glycine are found to homogeneously distribute throughout the cortical regions of the hair. The ability to selectively detect molecular agents in hair fibers is of direct relevance to understanding the chemical and physical mechanisms that underlie the performance of hair-care products.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Maxwell Zimmerley ; Chia-Yu Lin ; David C. Oertel ; Jennifer M. Marsh ; Jimmie L. Ward, et al.
"Quantitative detection of chemical compounds in human hair with coherent anti-Stokes Raman scattering microscopy", J. Biomed. Opt. 14(4), 044019 (August 05, 2009). ; http://dx.doi.org/10.1117/1.3184444


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