Research Papers

Photothermoacoustic imaging of biological tissues: maximum depth characterization comparison of time and frequency-domain measurements

[+] Author Affiliations
Sergey A. Telenkov, Andreas Mandelis

University of Toronto, Center for Advanced Diffusion-Wave Technologies, Department of Mechanical and Industrial Engineering, 5 King’s College Road, Toronto, Ontario M5S 3G8, Canada

J. Biomed. Opt. 14(4), 044025 (August 07, 2009). doi:10.1117/1.3200924
History: Received March 19, 2009; Revised May 25, 2009; Accepted June 15, 2009; Published August 07, 2009
Text Size: A A A

The photothermoacoustic (PTA) or photoacoustic (PA) effect induced in light-absorbing materials can be observed either as a transient signal in time domain or as a periodic response to modulated optical excitation. Both techniques can be utilized for creating an image of subsurface light-absorbing structures (chromophores). In biological materials, the optical contrast information can be related to physiological activity and chemical composition of a test specimen. The present study compares experimentally the two PA imaging modalities with respect to the maximum imaging depth achieved in scattering media with optical properties similar to biological tissues. Depth profilometric measurements were carried out using a dual-mode laser system and a set of aqueous light-scattering solutions mimicking photon propagation in tissue. Various detection schemes and signal processing methods were tested to characterize the depth sensitivity of PA measurements. The obtained results demonstrate the capabilities of both techniques and can be used in specific PTA imaging applications for development of image reconstruction algorithms aimed at maximizing system performance. Our results demonstrate that submillimeter-resolution depth-selective PA imaging can be achieved without nanosecond-pulsed laser systems by appropriate modulation of a continuous laser source and a signal processing algorithm adapted to specific parameters of the PA response.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Sergey A. Telenkov and Andreas Mandelis
"Photothermoacoustic imaging of biological tissues: maximum depth characterization comparison of time and frequency-domain measurements", J. Biomed. Opt. 14(4), 044025 (August 07, 2009). ; http://dx.doi.org/10.1117/1.3200924


Tables

Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Related Book Chapters

Topic Collections

Advertisement


  • Don't have an account?
  • Subscribe to the SPIE Digital Library
  • Create a FREE account to sign up for Digital Library content alerts and gain access to institutional subscriptions remotely.
Access This Article
Sign in or Create a personal account to Buy this article ($20 for members, $25 for non-members).
Access This Proceeding
Sign in or Create a personal account to Buy this article ($15 for members, $18 for non-members).
Access This Chapter

Access to SPIE eBooks is limited to subscribing institutions and is not available as part of a personal subscription. Print or electronic versions of individual SPIE books may be purchased via SPIE.org.