Research Papers

Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography

[+] Author Affiliations
Meng-Tsan Tsai, Cheng-Kuang Lee, Hsiang-Chieh Lee

National Taiwan University, Institute of Photonics and Optoelectronics, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan

Hsin-Ming Chen, Chun-Pin Chiang

National Taiwan University, School of Dentistry, 1 Roosevelt Road, Section 4, Taipei, 10048, Taiwan

Yih-Ming Wang

National Taiwan University, Institute of Photonics and Optoelectronics, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan

Chih-Chung Yang

National Taiwan University, Institute of Photonics and Optoelectronics and Department of Electrical Engineering, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan

J. Biomed. Opt. 14(4), 044028 (August 07, 2009). doi:10.1117/1.3200936
History: Received April 01, 2009; Revised June 14, 2009; Accepted June 16, 2009; Published August 07, 2009
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A swept-source optical coherence tomography (SS-OCT) system is used to clinically scan oral lesions in different oral carcinogenesis stages, including normal oral mucosa control, mild dysplasia (MiD), moderate dysplasia (MoD), early-stage squamous cell carcinoma (ES-SCC), and well-developed SCC (WD-SCC), for diagnosis purpose. On the basis of the analyses of the SS-OCT images, the stages of dysplasia (MiD and MoD), and SCC (ES-SCC and WD-SCC) can be differentiated from normal control by evaluating the depth-dependent standard deviation (SD) values of lateral variations. In the dysplasia stage, the boundary between the epithelium (EP) and lamina propria (LP) layers can still be identified and the EP layer becomes significantly thicker than that of normal control. Also, in a certain range of the EP layer above the EP/LP boundary, the SD value becomes larger than a certain percentage of the maximum level, which is observed around the EP/LP boundary. On the other hand, in the ES-SCC and WD-SCC stages, the EP/LP boundary disappears. Because of the higher density of connective tissue papillae in the ES-SCC stage, the SD values of the slowly varying lateral scan profiles in the ES-SCC samples are significantly larger than those in the WD-SCC sample. Also, ES-SCC can be differentiated from WD-SCC by comparing the exponential decay constants of averaged A-mode scan profiles. Because of the higher tissue absorption in the WD-SCC lesion, the decay constants in the WD-SCC samples are significantly higher than those in the ES-SCC samples.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Meng-Tsan Tsai ; Cheng-Kuang Lee ; Hsiang-Chieh Lee ; Hsin-Ming Chen ; Chun-Pin Chiang, et al.
"Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography", J. Biomed. Opt. 14(4), 044028 (August 07, 2009). ; http://dx.doi.org/10.1117/1.3200936


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