Research Papers

Simulation of reflected light intensity changes during navigation and radio-frequency lesioning in the brain

[+] Author Affiliations
Johannes D. Johansson, Ingemar Fredriksson, Karin Wårdell, Ola Eriksson

Linköping University, Department of Biomedical Engineering, S-581 85 Linköping, Sweden

J. Biomed. Opt. 14(4), 044040 (August 28, 2009). doi:10.1117/1.3210781
History: Received December 03, 2008; Revised June 04, 2009; Accepted June 30, 2009; Published August 28, 2009
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An electrode with adjacent optical fibers for measurements during navigation and radio frequency lesioning in the brain is modeled for Monte Carlo simulations of light transport in brain tissue. Relative reflected light intensity at 780nm, I780, from this electrode and probes with identical fiber configuration are simulated using the intensity from native white matter as reference. Models are made of homogeneous native and coagulated gray, thalamus, and white matter as well as blood. Dual layer models, including models with a layer of cerebrospinal fluid between the fibers and the brain tissue, are also made. Simulated I780 was 0.16 for gray matter, 0.67 for coagulate gray matter, 0.36 for thalamus, 0.39 for coagulated thalamus, unity for white matter, 0.70 for coagulated white matter, and 0.24 for blood. Thalamic matter is also found to reflect more light than gray matter and less than white matter in clinical studies. In conclusion, the reflected light intensity can be used to differentiate between gray and white matter during navigation. Furthermore, coagulation of light gray tissue, such as the thalamus, might be difficult to detect using I780, but coagulation in darker gray tissue should result in a rapid increase of I780.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Johannes D. Johansson ; Ingemar Fredriksson ; Karin Wårdell and Ola Eriksson
"Simulation of reflected light intensity changes during navigation and radio-frequency lesioning in the brain", J. Biomed. Opt. 14(4), 044040 (August 28, 2009). ; http://dx.doi.org/10.1117/1.3210781


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