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Research Papers

Diagnosis of oral submucous fibrosis with optical coherence tomography

[+] Author Affiliations
Cheng-Kuang Lee, Meng-Tsan Tsai, Hsiang-Chieh Lee

National Taiwan University, Institute of Photonics and Optoelectronics, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan

Hsin-Ming Chen, Chun-Pin Chiang

National Taiwan University, School of Dentistry, Taipei, 10048, Taiwan

Yih-Ming Wang

National Taiwan University, Institute of Photonics and Optoelectronics, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan

C. C. Yang

National Taiwan University, Institute of Photonics and Optoelectronics, 1 Roosevelt Road, Section 4, Taipei, 10617, Taiwan and National Taiwan University, Department of Electrical Engineering, Taipei, 10617, Taiwan

J. Biomed. Opt. 14(5), 054008 (February 27, 2009June 16, 2009July 14, 2009September 22, 2009). doi:10.1117/1.3233653
History: Received February 27, 2009; Revised June 16, 2009; Accepted July 14, 2009; Published September 22, 2009
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The epithelium (EP) thickness and the standard deviation (SD) of A-mode scan intensity in the laminar propria (LP) layer are used as effective indicators for the diagnosis of oral submucous fibrosis (OSF) based on the noninvasive clinical scanning of a swept-source optical coherence tomography (OCT) system of ∼6 μm in axial resolution (in tissue) and 103 dB in sensitivity. Compared with the corresponding parameters in healthy oral mucosal mucosa, in OSF mucosa, the EP thickness becomes smaller and the SD of A-mode scan intensity in the LP layer (LP SD) also becomes smaller. The LP SD can also be used for effectively differentiating OSF (small LP SD) from lesion (large LP SD). This application is particularly useful in the case of a lesion without a clear surface feature. Meanwhile, the use of the SD of A-mode scan intensity in the EP layer (EP SD) can further help in differentiating OSF (medium EP SD) from healthy oral mucosal (small EP SD) and lesion (large EP SD) conditions. Compared with the conventional method of maximum mouth opening measurement, the use of the proposed OCT scanning results can be a more effective technique for OSF diagnosis.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Cheng-Kuang Lee ; Hsin-Ming Chen ; Yih-Ming Wang ; C. C. Yang ; Chun-Pin Chiang, et al.
"Diagnosis of oral submucous fibrosis with optical coherence tomography", J. Biomed. Opt. 14(5), 054008 (February 27, 2009June 16, 2009July 14, 2009September 22, 2009). ; http://dx.doi.org/10.1117/1.3233653


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