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Research Papers

Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis

[+] Author Affiliations
Zhen Yuan, Qizhi Zhang

University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611-6131

Eric Sobel

University of Florida, College of Medicine, Division of Rheumatology, P.O. Box 100221, Gainesville, Florida 32611

Huabei Jiang

University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611-6131

J. Biomed. Opt. 14(5), 054013 (October 07, 2009). doi:10.1117/1.3233655
History: Received December 02, 2008; Revised July 20, 2009; Accepted July 25, 2009; Published October 07, 2009
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In this study, a simplified spherical harmonics approximated higher order diffusion model is employed for 3-D diffuse optical tomography of osteoarthritis in the finger joints. We find that the use of a higher-order diffusion model in a stand-alone framework provides significant improvement in reconstruction accuracy over the diffusion approximation model. However, we also find that this is not the case in the image-guided setting when spatial prior knowledge from x-rays is incorporated. The results show that the reconstruction error between these two models is about 15 and 4%, respectively, for stand-alone and image-guided frameworks.

Figures in this Article
© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Zhen Yuan ; Qizhi Zhang ; Eric Sobel and Huabei Jiang
"Comparison of diffusion approximation and higher order diffusion equations for optical tomography of osteoarthritis", J. Biomed. Opt. 14(5), 054013 (October 07, 2009). ; http://dx.doi.org/10.1117/1.3233655


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