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Research Papers

Diffuse optical spectroscopy of breast tissue extended to 1100nm

[+] Author Affiliations
Paola Taroni

Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, Istituto di Fotonica e Nanotecnologie, Piazza Leonardo da Vinci 32, Milan, 20133, Italy

Andrea Bassi

Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, National Laboratory for Ultrafast and Ultraintense Optical Science, Piazza Leonardo da Vinci 32, Milan, 20133, Italy

Daniela Comelli, Andrea Farina

Politecnico di Milano, Dipartimento di Fisica, Piazza Leonardo da Vinci 32, Milan, 20133, Italy

Rinaldo Cubeddu, Antonio Pifferi

Politecnico di Milano, Dipartimento di Fisica and Consiglio Nazionale delle Ricerche, National Laboratory for Ultrafast and Ultraintense Optical Science, Piazza Leonardo da Vinci 32, Milan, 20133, Italy

J. Biomed. Opt. 14(5), 054030 (October 28, 2009). doi:10.1117/1.3251051
History: Received April 02, 2009; Revised August 07, 2009; Accepted August 11, 2009; Published October 28, 2009
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The feasibility of in vivo measurements in the range of 1000to1100nm and the potential benefits of operation in that wavelength range for diagnostic applications are investigated. To this purpose, an existing system for time-resolved diffuse spectroscopy is modified to enable in vivo studies to be carried out continuously from 600to1100nm. The optical characterization of collagen powder is extended to 1100nm and an accurate measurement of the absorption properties of lipid is carried out over the entire spectral range. Finally, the first in vivo absorption and scattering spectra of breast tissue are measured from 10 healthy volunteers between 600 and 1100nm and tissue composition is evaluated in terms of blood parameters and water, lipid, and collagen content using a spectrally constrained global fitting procedure.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Paola Taroni ; Andrea Bassi ; Daniela Comelli ; Andrea Farina ; Rinaldo Cubeddu, et al.
"Diffuse optical spectroscopy of breast tissue extended to 1100nm", J. Biomed. Opt. 14(5), 054030 (October 28, 2009). ; http://dx.doi.org/10.1117/1.3251051


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