Research Papers

Experimental investigation of evanescence-based infrared biodetection technique for micro-total-analysis systems

[+] Author Affiliations
Arvind Chandrasekaran, Muthukumaran Packirisamy

Concordia University, Department of Mechanical Engineering, Optical-Bio Microsystems Laboratory, 1515 Street Catherine Ouest, Montreal, Quebec H3G 2W1, Canada

J. Biomed. Opt. 14(5), 054050 (October 30, 2009). doi:10.1117/1.3210766
History: Received October 20, 2008; Revised February 03, 2009; Accepted February 11, 2009; Published October 30, 2009
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The advent of microoptoelectromechanical systems (MOEMS) and its integration with other technologies such as microfluidics, microthermal, immunoproteomics, etc. has led to the concept of an integrated micro-total-analysis systems (μTAS) or Lab-on-a-Chip for chemical and biological applications. Recently, research and development of μTAS have attained a significant growth rate over several biodetection sciences, in situ medical diagnoses, and point-of-care testing applications. However, it is essential to develop suitable biophysical label-free detection methods for the success, reliability, and ease of use of the μTAS. We proposed an infrared (IR)-based evanescence wave detection system on the silicon-on-insulator platform for biodetection with μTAS. The system operates on the principle of bio-optical interaction that occurs due to the evanescence of light from the waveguide device. The feasibility of biodetection has been experimentally investigated by the detection of horse radish peroxidase upon its reaction with hydrogen peroxide.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Arvind Chandrasekaran and Muthukumaran Packirisamy
"Experimental investigation of evanescence-based infrared biodetection technique for micro-total-analysis systems", J. Biomed. Opt. 14(5), 054050 (October 30, 2009). ; http://dx.doi.org/10.1117/1.3210766


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