Research Papers

Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study

[+] Author Affiliations
Yao Sun

University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611

Eric Sobel

Universiry of Florida, Divison of Rheumatology, College of Medicine, Gainesville, Florida 32611

Huabei Jiang

University of Florida, Department of Biomedical Engineering, 130 BME Building, P.O. Box 116131, Gainesville, Florida 32611

J. Biomed. Opt. 14(6), 064002 (November 04, 2009). doi:10.1117/1.3257246
History: Received February 05, 2009; Revised May 26, 2009; Accepted September 08, 2009; Published November 04, 2009
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We present for the first time in vivo full three-dimensional (3-D) photoacoustic tomography (PAT) of the distal interphalangeal joint in a human subject. Both absorbed energy density and absorption coefficient images of the joint are quantitatively obtained using our finite-element-based photoacoustic image reconstruction algorithm coupled with the photon diffusion equation. The results show that major anatomical features in the joint along with the side arteries can be imaged with a 1-MHz transducer in a spherical scanning geometry. In addition, the cartilages associated with the joint can be quantitatively differentiated from the phalanx. This in vivo study suggests that the 3-D PAT method described has the potential to be used for early diagnosis of joint diseases such as osteoarthritis and rheumatoid arthritis.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Yao Sun ; Eric Sobel and Huabei Jiang
"Quantitative three-dimensional photoacoustic tomography of the finger joints: an in vivo study", J. Biomed. Opt. 14(6), 064002 (November 04, 2009). ; http://dx.doi.org/10.1117/1.3257246


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