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Research Papers

Whole-body three-dimensional optoacoustic tomography system for small animals

[+] Author Affiliations
Matthew Fronheiser

Seno Medical Instruments, Inc., 3838 Medical Drive, San Antonio, Texas 78230

Sergey A. Ermilov, Andre Conjusteau, Alexander A. Oraevsky

Fairway Medical Technologies, Inc., 9431 West Sam Houston Parkway South, Houston, Texas 77099

Hans-Peter Brecht, Richard Su

Fairway Medical Technologies, Inc., 9431 West Sam Houston Parkway South, Houston, Texas 77099

J. Biomed. Opt. 14(6), 064007 (May 19, 2009August 21, 2009September 10, 2009November 18, 2009November 18, 2009). doi:10.1117/1.3259361
History: Received May 19, 2009; Revised August 21, 2009; Accepted September 10, 2009; Published November 18, 2009; Online November 18, 2009
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We develop a system for three-dimensional whole-body optoacoustic tomography of small animals for applications in preclinical research. The tomographic images are obtained while the objects of study (phantoms or mice) are rotated within a sphere outlined by a concave arc-shaped array of 64 piezocomposite transducers. Two pulsed lasers operating in the near-IR spectral range (755 and 1064nm) with an average pulsed energy of about 100mJ, a repetition rate of 10Hz, and a pulse duration of 15to75ns are used as optical illumination sources. During the scan, the mouse is illuminated orthogonally to the array with two wide beams of light from a bifurcated fiber bundle. The system is capable of generating images of individual organs and blood vessels through the entire body of a mouse with spatial resolution of 0.5mm.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Matthew Fronheiser ; Sergey A. Ermilov ; Hans-Peter Brecht ; Richard Su ; Andre Conjusteau, et al.
"Whole-body three-dimensional optoacoustic tomography system for small animals", J. Biomed. Opt. 14(6), 064007 (May 19, 2009August 21, 2009September 10, 2009November 18, 2009November 18, 2009). ; http://dx.doi.org/10.1117/1.3259361


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