Research Papers

Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography

[+] Author Affiliations
Christopher Drew

Virginia Tech, Mechanical Engineering, MC-0298 ICTAS Building, Stanger Street, Room 325, Blacksburg, Virginia 24061

Thomas E. Milner

University of Texas at Austin, Biomedical Engineering, 1 University Station, C0800, Austin, Texas 78712

Christopher G. Rylander

Virginia Tech, Mechanical Engineering, Biomedical Engineering and Sciences, MC-0298 ICTAS Building, Stanger Street, Room 325, Blacksburg, Virginia 24061

J. Biomed. Opt. 14(6), 064019 (December 07, 2009). doi:10.1117/1.3268441
History: Received May 18, 2009; Revised September 07, 2009; Accepted September 23, 2009; Published December 07, 2009; Online December 07, 2009
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We report results of a study to evaluate effectiveness of a mechanical tissue optical clearing device (TOCD) using optical coherence tomography (OCT). The TOCD uses a pin array and vacuum pressure source to compress localized regions of the skin surface. OCT images (850 and 1310nm) of in vivo human skin indicate application of the TOCD provides an up to threefold increased light penetration depth at spatial positions correlated with pin indentations. Increased contrast of the epidermal–dermal junction in OCT images spatially correlates with indented zones. OCT M-scans recorded while applying the TOCD indicate optical penetration depth monotonically increased, with most improvement at early times (5to10s) of TOCD vacuum application. OCT M-scans of ex vivo porcine skin compressed using the TOCD suggest average group refractive index of the tissue increased, corresponding to a decrease in water concentration. Results of our study indicate that mechanical optical clearing of skin may provide an effective and efficient means to deliver increased light fluence to dermal and subdermal regions.

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© 2009 Society of Photo-Optical Instrumentation Engineers

Citation

Christopher Drew ; Thomas E. Milner and Christopher G. Rylander
"Mechanical tissue optical clearing devices: evaluation of enhanced light penetration in skin using optical coherence tomography", J. Biomed. Opt. 14(6), 064019 (December 07, 2009). ; http://dx.doi.org/10.1117/1.3268441


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