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Special Section on Optical Methods in Vascular Biology and Medicine

Fluorescence lifetime in cardiovascular diagnostics

[+] Author Affiliations
Laura Marcu

University of California, Davis, Department of Biomedical Engineering, Davis, California 95616

J. Biomed. Opt. 15(1), 011106 (March 01, 2010). doi:10.1117/1.3327279
History: Received June 01, 2009; Accepted December 16, 2009; Published March 01, 2010; Online March 01, 2010
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We review fluorescence lifetime techniques including time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.

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© 2010 Society of Photo-Optical Instrumentation Engineers

Citation

Laura Marcu
"Fluorescence lifetime in cardiovascular diagnostics", J. Biomed. Opt. 15(1), 011106 (March 01, 2010). ; http://dx.doi.org/10.1117/1.3327279


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